Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02022Silvadene--
BADD_D02026Simvastatin--
BADD_D02028Sirolimus--
BADD_D02058Sorafenib0.000278%
BADD_D02062Sparfloxacin--
BADD_D02088Sulfacetamide--
BADD_D02090Sulfadiazine--
BADD_D02091Sulfamethoxazole--
BADD_D02093Sulfasalazine0.000360%
BADD_D02105Tacrolimus--
BADD_D02111Tamoxifen--
BADD_D02112Tamoxifen citrate--
BADD_D02146Telithromycin--
BADD_D02155Tenofovir disoproxil0.002318%
BADD_D02199Thioguanine--
BADD_D02215Ticlopidine--
BADD_D02216Ticlopidine hydrochloride--
BADD_D02230Tizanidine--
BADD_D02290Trimethoprim--
BADD_D02302Tromethamine--
BADD_D02367Voltaren--
BADD_D02394Zolpidem0.000028%
BADD_D02436Atorvastatin0.000069%
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ADReCS-Target
ADR Term Drug Name Target